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Science : tissue regeneration

How do tissues fight against infection and regenerate?

Inflammation resolution may indeed be involved in these fascinating biological processes through the action of the SPMs (Specialized Pro-resolving Mediators). 

In this recent publication, Chiang et al. identified genes and pathways that might link resolution of inflammation and regeneration using planaria model. They showed how tissue regeneration is regulated by cys-SPMs pathways, and in particular by TRAF3. TRAF3 indeed contributes to cys-SPM–stimulated phagocyte functions and resolution of infection.

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Science : eye Health

On the trail of new strategies to treat conjunctivitis or dry eye disease with specialized pro-resolving mediators ?

SPM are Omega-3 derived lipids that activate biological defense mechanisms as inflammation resolution.

In this recent publication, Olsen et al. report how maresin 1(MaR1) regulates tear film mucin levels by controlling [Ca2+] levels. These findings suggest that MaR1 or its mimetic analogs could be a novel treatment for different inflammatory diseases spanning from allergic conjunctivitis to dry eye disease.

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Science : Specialized Pro-resolving Mediators and COVID19

How Omega-3 derived lipids may protect us against infections and give rise to new generation therapies?

Indeed, specialized pro-resolving mediators (SPMs) are Omega-3 derived lipids that are naturally present in our body. They are necessary to activate biological defense mechanisms (as inflammation resolution) and hold strong therapeutic potentials in the management of COVID-19.

In this recent publication, Balta et al. address the molecular events that link the lipid mediators with COVID-19 severity and discuss the clinical potentials of SPMs in COVID-19 immunotherapeutics.

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