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Science Articles about Inflammation Resolution

Here are interesting recent science articles about inflammation resolution :

20 science pharma

From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution, Tran Thi Van Anh, Alilou Mostafa, Zhigang Rao, Simona Pace, Stefan Schwaiger, Christian Kretzer, Veronika Temml, Carsten Giesel, Paul M. Jordan, Rossella Bilancia, Christina Weinigel, Silke Rummler, Birgit Waltenberger, Tran Hung, Antonietta Rossi, Hermann Stuppner, Oliver Werz, Andreas Koeberle, Acta Pharmaceutica Sinica B (2021), DOI : https://doi.org/10.1016/j.apsb.2021.04.011 

Plant extract with anti-inflammatory AND pro-resolving properties

In search of the Grail for chronic inflammation therapeutic strategy : A promising drug candidate that combines 5-lipoxygenase inhibition with...

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Ambiotis new publication : inflammation resolution and sleep

How inflammation resolution may support a better sleep recovery?

Ambiotis is very proud to share this great publication resulting from a solid collaborative work between Israel Deaconess Medical Center, the Harvard Medical School and Ambiotis !

This new scientific publication is entitled :“Greater NREM Sleep Rebound in Response to Experimental Sleep Disturbance Associated with Higher Inflammatory Resolution in Humans”.  These data suggest that during recovery from sleep disturbance, NREM (non-rapid eye movement) sleep promotes inflammatory resolution, thereby acting as the sleep state that protects against low-grade systemic inflammation, which has been frequently observed as a consequence of sleep disturbances.

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Check the publication here :“Greater NREM Sleep Rebound in Response to Experimental Sleep Disturbance Associated with Higher Inflammatory Resolution in Humans”. 

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Science : plant extract with anti-inflammatory AND pro-resolving properties

Plant extract with anti-inflammatory AND pro-resolving properties

In search of the Grail for chronic inflammation therapeutic strategy : A promising drug candidate that combines 5-lipoxygenase inhibition with the favorable reprogramming of lipid mediator profiles.

Switching from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation, but very few molecules showing such properties have ever been found.

In this recent publication, Van Han et al. identified a molecule from vietnamese medical plant extracts (Dracaena cambodiana), which limit inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile from leukotrienes to specialized pro-resolving mediators (SPM).

A remarkable work, from screening of a medical plant library to biological assessment and suggestion of mechanisms of action. They showed that leukotriene production is efficiently suppressed in activated human neutrophils, macrophages, and blood, while the induction of SPM biosynthesis is restricted to M2 macrophages. The shift from leukotrienes to SPM was also evident in mouse peritonitis in vivo.

More information about this article entitled "From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution" : click here

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