Approaches on cellular model or skin explants for a market-oriented positioning
(cutaneous protection, anti-pollution, anti-aging, defense, fight against acne or other skin diseases)

Expertise of Ambiotis

Ambiotis is a research-based company specialized in well-being and tissue homeostasis. Inflammatory components are described in most skin troubles from irritations up to psoriasis, atopic dermatitis and aging.

Ambiotis has thus developed a broad range of innovative cellular tests to evaluate the efficiency of active ingredients on skin protection against homeostasis rupture, pollution, ageing, irritations, scars, atopic dermatitis, psoriasis…

Innovative concepts for dermo-cosmetic products

Homeostasis protection
Evaluate how your active can protect and maintain an healthy balance of the skin by boosting resolutive molecules
Evaluate your active for innovative anti-pollution activity on cells or skin models
Evaluate your active for anti-irritation activity on cells or skin models
Barrier function/Defense
Evaluate how a compound can enhance barrier function against water loss, pathogens…
Learn if your active is able to counterbalance bad effects of aging (elasticity loss, low grade inflammation…)
Evaluate if your active allows to fight against bacteria, associated inflammation or to regulate sebum production
Evaluate the capacities of actives to correctly end inflammatory events and avoid scars
Evaluate impact of actives on pigmentation on human melanocytes
Skin diseases
Evaluate inflammatory and immunomodulatory impacts of compounds in relevant human cell models (skin, monocytes, macrophages, lymphocytes, co-culture ...
Evaluate impact of actives on lipolysis activity in adipocytes


We can also address chronobiology, oxidative stress… Do not hesitate to ask for more informations

How to evaluate actives for skin protection against homeostasis rupture, pollution, aging, skin diseases…?

Inflammation is a natural response of the tissue to irritation or rupture of microbiota balance and proliferation of unwanted microorganisms. If correctly controlled, it leads to resolution and allow the tissue to go back to homeostasis.

Resolution is characterized by the natural and sequential synthesis of specialized mediators (resolvins, protectins, lipoxins, maresins) or SPMs. These mediators are essential to induce correct healing, maintain tissue balance and avoid skin discomfort, scars or even chronic inflammation.

SPMs have known biological and beneficial activities in many inflammatory contexts including aging, atopic dermatitis, psoriasis, tissue healing and soothing.

Il est ainsi devenu essentiel de compléter l'approche anti-inflammatoire (évaluer les effets inhibiteurs d’ingrédients sur la production de médiateurs pro-inflammatoires) d'une approche pro-résolution (évaluer les effets activateurs d’ingrédients sur la production de résolvines, protectines, marésines et lipoxines) afin de contrôler la restauration effective du tissu.

It has thus become essential to complete an anti-inflammatory approach (evaluate inhibitory effects of ingredients on pro-inflammatory mediators) with a pro-resolution one (evaluate activating effects of ingredients on resolvin, protectin, maresin and lipoxin production) to ensure an effective tissue restoration.

From screening to efficacy validation

Cell-based assays: human primary cell models

  • Pre-adipocytes and adipocytes
  • Keratinocytes
  • Fibroblasts
  • Melanocytes
  • Immunity cells (dendritic and Langerhans cells, monocytes, macrophages, neutrophils, lymphocytes)
  • Co-culture to mimic skin compartment
  • Reconstructed human skin
  • Skin explant

Senescence can be chemically induced in skin cells.

Donors can be chosen based on their age and sex.

Analytical services

Ways of working with us


Step 1: your need

  • Understanding of your need
  • Orientation toward the relevant work package

- analytical package : provide us with samples to be analyzed

- model-based package : provide us with your compounds to evaluate

- Customized development

- Scientific consulting

Step 2: our collaboration

  • Performance of services according milestones and go/no go steps
  • Regular follow-up

Step 3: your results

  • Scientific feedback through webex conference
  • Final report
  • Follow up

Contact us

+33 (0)5 62 24 41 57

+33 (0)5 61 25 64 02

Send an e-mail via the form

Canal Biotech 2 - 3 Rue des satellites 31400 Toulouse - France

Receive our news

Recent news

Ambiotis - - Copyright © 2017 - All rights reserved - Legal Notice