How do tissues fight against infection and regenerate?
Inflammation resolution may indeed be involved in these fascinating biological processes through the action of the SPMs (Specialized Pro-resolving Mediators).
In this recent publication, Chiang et al. identified genes and pathways that might link resolution of inflammation and regeneration using planaria model. They showed how tissue regeneration is regulated by cys-SPMs pathways, and in particular by TRAF3. TRAF3 indeed contributes to cys-SPM–stimulated phagocyte functions and resolution of infection.