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Ambiotis provides preclinical tests and brings scientific proofs to answer the requirements of the Regulation (EC) 1924/2006 of 20 December 2006 (articles 13 and 14). Ambiotis helps get more easily any health claim related to the inflammatory process.

The results make the proof of concept of functional food, and establish the basics of health benefits related to:

Interest for Ambiotis' business partners :
1. support for the making of a health claim file containing:
  • screening on cell models
  • proof of concept on functional models (cell and animal)
  • rationalization of the active ingredient discovery
2. answer to legal requirements by using biomarkers measuring the effects of functional food on inflammatory-related events

3. design of clinical trials : Cost control

4. objectivation of your communication with purchasing advisors and business partners

  - Intestinal comfort improvment


Testable compounds: dairy products, dietary fibres, prebiotics, probiotics, …

Colitis is a digestive disease characterized by inflammation of the colon. People affected by colitis suffer from intestinal troubles (abdominal pain, diarrhea, bloating). Ambiotis is an inflammatory process expert, and has developed original animal models that mimic colitis symptoms (an “acute” colitis model, which mimics the symptoms of a short in time and acute crisis and a “chronic” colitis model, which mimics symptoms of a continuous and disturbing pain).

Ambiotis’ animal tests provide scientific proofs to demonstrate clearly whether any active compound has an effect on the origins of colitis. Since the biomarkers investigated on animal models are same as the human ones, the provided results are helpful for the setup of clinical trials focused on the improvement people’s intestinal comfort by functional food.

   - Bad cholesterol protection


Testable compounds: nicotinic acid, niacin, polyunsaturated fatty acids (DHA/EPA, omega-3, omega-6), lysine, wild-fish-oil, wheat germ, …

Several kinds of cholesterol circulate through the blood. LDL (Low Density Lipoprotein) is known as “bad” cholesterol. A high level of LDL leads to a slow obstruction of blood vessels, called atheromatous plaque. The consequence is an increase of the risk of stroke (brain attack) and myocardial infarction (heart attack). Overweight and hypertension are increasing factors. It has been scientifically demonstrated that cardiovascular diseases are actually chronic inflammatory diseases, and their origin is related to the atheromatous plaque.

Ambiotis develops models that mimic the atheromatous plaque full of “bad” cholesterol in order to make the proof of concept of functional food. The results are useful for the setup of vivo and clinical protocols to demonstrate human health benefits.


- Cell ageing and oxydative stress protection


Testable compounds: β-carotene, betalains, coffee, copper, flavonoids, fruit extracts, royal gelly, wheat germ, glutamin, dairy products, lycopen, vegetable extracts, honey, fruit seeds, polyphenols, selenium, taurin, tea, quercetin, vitamin C, vitamin E, …

Reactive Oxygen Species (ROS), also called Free Radicals (FR), are molecules involved in the care and the natural functioning of the body. However, they are also involved in some nasty pathways (oxidative stress), which lead to cell early-aging.

Ambiotis develops reliable models to quantify oxidation. The provided results are helpful for the setup of studies demonstrating health benefits of functional food on people, by slowing down the mechanisms related to oxidative stress.


  - Immune system strengthening


Testable compounds: aloe vera, arginin, bovine colostrum, brewer yeast, dietary fibre, folic acid, glutamin, iron, isoleucin, leucin, lysin, milk phospholipids, papain, polyunsaturated fatty acids, prebiotics, probiotics, promelain, shark cartilage, vitamin A, vitamin B6, vitamin C, vitamin E, wheat germ, zinc, …

The immune system is a natural body protection against diseases (flu, cold, cancer, …). Many factors are involved in the weakening of the immune system: aging, tiredness, stress, tobacco smoking, bacteria, viruses, … Having a strong immune system means thus being in good health.

Ambiotis is an immunity expert, and develops reliable tests to measure accurately the biomarkers involved in the immune response. The provided results are helpful to set up clinical trials demonstrating health benefits of functional food, by boosting the immune system of people.



Regulation 1924/2006 (20 december 2006) at http://eur-lex.europa.eu/LexUriServ/site/fr/oj/2006/l_404/l_40420061230fr00090025.pdf.


© European community, http://eur-lex.europa.eu/

Seule fait foi la version imprimée de la législation européenne telle que publiée dans les éditions papier du Journal Officiel de l’Union Européenne.

Ambiotis - Incubateur MIPY 29 rue Jeanne Marvig 31400 Toulouse - tél: +33 (0)5 62 24 41 57 - fax: +33 (0)5 61 32 22 93 - contact@ambiotis.com - www.ambiotis.com